Snake venom toxin from vipera lebetina turanicainduces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression
نویسندگان
چکیده
منابع مشابه
Vipera lebetina venom contains all types of snake venom metalloproteases.
Snake venoms contain four classes of metalloproteases that all have a typical zinc-chelating sequence (HEXXHGXXH). N-terminal sequences and internal sequences of different purified metalloproteases were determined using Edman sequencing and LC MS/MS technique. Oligonucleotides were designed and used as primers for cDNA cloning from Vipera lebetina venom gland cDNA library. We found that isoform...
متن کاملCytotoxic Effect of Iranian Vipera Lebetina snake Venom on HUVEC Cells
Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was to evaluate the...
متن کاملAntiadhesive and cytotoxic effect of Iranian Vipera lebetina snake venom on lung epithelial cancer cells
Background Cancer is one of the major health problems worldwide. Hence, finding potent therapeutics from natural sources seems necessary. Snake venom of Vipera lebetina contains potential component with anticancer activities such as antiproliferation, migration, invasion, adhesion, and angiogenesis effect. Evaluation of cytotoxic and antiadhesive effect of V. lebetina venom on lung epithelial c...
متن کاملCytotoxic Effect of Iranian Vipera Lebetina snake Venom on HUVEC Cells
Objective: Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was to evaluate the...
متن کاملCytotoxic Effect of Iranian Vipera lebetina Snake Venom on HUVEC Cells
OBJECTIVE Envenomation by heamotoxic snakes constituted a critical health occurrence in the world. Bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. It is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. This study was carried out to e...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2012
ISSN: 1471-2407
DOI: 10.1186/1471-2407-12-228